PHK: A Protein with Potential as A Drug Or Biomarker (P12248)

Target Name: Phosphorylase kinase

NCBI ID: P12248

Phosphorylase kinase

Other Name(s): PHK

PHK: A Protein with Potential as A Drug Or Biomarker

Phosphorylase kinase (nonspecific subunit), also known as PHK, is an enzyme that plays a crucial role in various cellular processes. It is a protein that is highly conserved across different species, and its function is to catalyze the phosphorylation of various amino acids, including tyrosine, threonine, and serine. The majority of PHK is found in the cytosol of eukaryotic cells, while smaller amounts are found in the mitochondria and endoplasmic reticulum.

PHK is a protein that can be targeted as a drug or biomarker in various diseases. One of the main reasons for its potential as a drug is its involvement in the signaling pathway of tyrosination, which is a post-translational modification that involves the addition of a phosphate group to a specific amino acid residue. This modification plays a crucial role in the regulation of various cellular processes, including cell signaling, DNA replication, and protein synthesis.

PHK is also a protein that has been implicated in the development and progression of various diseases, including cancer. In fact, studies have shown that PHK is often expressed at higher levels in cancer cells compared to normal cells. This is because cancer cells often have increased tyrosination, which can lead to the formation of new blood vessels, a process that can contribute to tumor growth.

Another potential use of PHK as a drug or biomarker is its role in the regulation of inflammation. PHK has been shown to play a role in the production of reactive oxygen species (ROS), which are highly reactive molecules that can cause damage to cellular components and contribute to the development of inflammation. By inhibiting the activity of PHK, researchers have found that they can reduce the production of ROS and improve the anti-inflammatory effects of drugs.

In addition to its potential as a drug or biomarker, PHK is also a protein that is of interest to researchers studying the structure and function of cells. Because it is a highly conserved protein, researchers have been able to use it as a tool for studying the mechanisms of protein folding and the regulation of various cellular processes.

Overall, PHK is a protein that has the potential to be a drug target or biomarker in various diseases. Its role in the regulation of tyrosination and inflammation makes it an attractive target for researchers, while its conserved nature makes it a valuable tool for studying protein biology. As research continues to advance, PHK is likely to provide new insights into the mechanisms of cellular signaling and the development of various diseases.

Protein Name: Phosphorylase Kinase (nonspecified Subtype)

The "Phosphorylase kinase Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about Phosphorylase kinase comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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